Summary: The DNAJ-PKAc fusion kinase is a defining feature Cable Markers of fibrolamellar carcinoma (FLC).FLC tumors are notoriously resistant to standard chemotherapies, with aberrant kinase activity assumed to be a contributing factor.By combining proximity proteomics, biochemical analyses, and live-cell photoactivation microscopy, we demonstrate
Net primary productivity (NPP), as an indicator of ecological functioning, plays an important role in regional and global carbon cycles.Although many studies have estimated the NPP of vegetation on the Qinghai Plateau (QP), the existing NPP datasets over the QP are either of low spatial resolution or limited-duration time-series.These shortcomings
Magnesium alloys are nontoxic and promising as orthopedic metallic implants, but preparing a biocompatible Mg(OH)2 layer with high corrosion protection ability remains challenging.It is generally believed that the Mg(OH)2 layer, especially that formed in a natural condition, cannot provide desirable corrosion resistance in the community of corrosio
A new set of hypotheses is presented regarding the cause of aggressive religious radicalization.It is grounded in classic and contemporary theory of human motivation and goal regulation, together with recent empirical advances in personality, social, and neurophysiological psychology.We specify personality traits, threats, and group affordances tha